Beilstein J. Org. Chem.2017,13, 1596–1660, doi:10.3762/bjoc.13.159
ulcerans, which exhibit cytotoxic, immunosuppressive and analgesic properties. As the virulence factor of M. ulcerans, mycolactones are central to the pathogenesis of the neglected disease Buruliulcer, a chronic and debilitating medical condition characterized by necrotic skin ulcers. Due to their complex
discussion of more recent contributions. Furthermore, a detailed discussion of molecular targets and structure–activity relationships is provided.
Keywords: Buruliulcer; mode of action; mycolactones; structure–activity relationships; target elucidation; total synthesis; Review
I. Mycolactones and Buruli
ulcerBuruliulcer is a chronic and debilitating disease characterized by skin ulcers and necrotic cutaneous lesions. Ulcers typically occur at the limbs and can extend to 15% of the skin surface if untreated. The disease is caused by the pathogen Mycobacterium ulcerans and represents the third most
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Graphical Abstract
Figure 1:
Initial proposal for the core macrolactone structure (left) and the established complete structure ...
Beilstein J. Org. Chem.2012,8, 290–299, doi:10.3762/bjoc.8.31
diseases such as leprosy, evoked by M. leprae, or buruliulcer, due to infection by M. ulcerans [3][4]. In addition, numerous nonpathogenic and facultative pathogenic mycobacteria exist.
Although several diagnostic measures have been developed for TB diagnosis [5][6], most of these techniques are expensive
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Graphical Abstract
Figure 1:
Volatile compounds released by Mycobacterium tuberculosis and M. bovis identified in previous studi...